Piperacillin/Tazobactam – 40 μg Antibiotic Disc – Bioanalyse

Piperacillin/Tazobactam – 40 μg Antibiotic Disc – Bioanalyse Overview

The Piperacillin/Tazobactam – 40 μg Antibiotic Disc – Bioanalyse is a critical diagnostic tool meticulously crafted for antimicrobial susceptibility testing. This high-quality paper disc, impregnated with a precise 40 microgram combination of Piperacillin (a potent broad-spectrum beta-lactam antibiotic) and Tazobactam (a crucial beta-lactamase inhibitor), is essential for laboratories performing the disc diffusion method. It empowers healthcare professionals to accurately determine bacterial susceptibility to this vital antibiotic combination, aiding in the selection of effective treatment regimens for a wide range of infections. Trust Bioanalyse quality for reliable and reproducible results in your clinical microbiology workflows.

Piperacillin/Tazobactam – 40 μg Antibiotic Disc – Bioanalyse Key Features

• Precise Impregnation: Each disc contains a standardized 40 μg concentration of Piperacillin/Tazobactam for consistent and reliable susceptibility testing.
• Broad-Spectrum Efficacy Testing: Designed to evaluate bacterial susceptibility against both Gram-positive and Gram-negative organisms, covering a wide array of potential pathogens.
• Facilitates Accurate Diagnosis: Essential for identifying effective treatment options for serious infections including UTIs, respiratory infections, skin and soft tissue infections, bone and joint infections, intra-abdominal infections, sepsis, and meningitis.
• Pre-Surgical Infection Prevention Support: Assists in identifying appropriate antibiotic prophylaxis to prevent post-operative infections.
• Standardized Performance: Manufactured under stringent quality controls to ensure reproducible results when used with standardized laboratory procedures.
• User-Friendly Application: Ready-to-use format simplifies the disc diffusion testing process for laboratory technicians.

Technical Specifications

• Product: Antibiotic Susceptibility Testing Disc
• Antibiotic Combination: Piperacillin/Tazobactam
• Concentration: 40 μg per disc
• Method Compatibility: Disc Diffusion Method
• Brand: Bioanalyse
• Quality Assurance: Manufactured to meet high standards for diagnostic reagents.
• Intended Use: In vitro diagnostic use for clinical microbiology laboratories.

Interpreting Results: Zone of Inhibition

The interpretation of bacterial susceptibility to Piperacillin/Tazobactam based on the disc diffusion method is guided by the diameter of the zone of inhibition, measured in millimeters (mm):

• ≥ 17 mm: Susceptible (Indicates the bacteria are likely inhibited by standard therapeutic doses.)
• 13-16 mm: Intermediate (Suggests that the bacteria may be inhibited by higher doses or if the infection is localized.)
• < 13 mm: Resistant (Indicates that the bacteria are unlikely to be inhibited by achievable concentrations of the antibiotic.)

Important Considerations and Limitations

While the Piperacillin/Tazobactam – 40 μg Antibiotic Disc – Bioanalyse is a valuable tool, it’s crucial to understand its limitations:

• Semi-Quantitative Nature: The disc diffusion method provides a semi-quantitative assessment. For more precise Minimum Inhibitory Concentration (MIC) values, methods like broth microdilution or agar dilution are recommended.
• Detection of Resistance: This method may not detect all forms of resistance. Certain resistant strains, such as some Pseudomonas aeruginosa, might not exhibit a clear zone of inhibition despite being resistant.
• Standardization is Key: Results are influenced by factors such as the type of agar medium used, incubation temperature, and the initial density of the bacterial inoculum. Adherence to standardized protocols (e.g., CLSI or EUCAST guidelines) is paramount for accurate and reproducible results.

Safety Information

Allergy Warning: Piperacillin/Tazobactam is a beta-lactam antibiotic. Individuals with known hypersensitivity or allergy to beta-lactam antibiotics (including penicillins and cephalosporins) should not handle or be exposed to this product. Allergic reactions can be severe.

Potential Side Effects: Use of Piperacillin/Tazobactam in clinical treatment can lead to serious adverse effects, including seizures and severe allergic reactions. This product is for in vitro diagnostic use only.

Caution with Pre-existing Conditions: Patients with a history of liver or kidney disease should be managed with caution under medical supervision when treated with Piperacillin/Tazobactam. This product is for laboratory testing, not direct patient administration.